In human lung tumors, miR-574-5p upregulation promotes tumor development in vivo and increases mPGES-1 expression by preventing CUGBP1 binding to the mPGES-1 3′UTR (decoy mechanism), which leads to an enhanced alternative splicing mPGES-1 and the generation of a novel 3′UTR isoform [130]. This evidence concerns the gene CELF1 and neoplasm.