SH3BGR and cardiac hypertrophy: Further, we observed an upregulation of SH3BGR protein levels in the hearts of human patients who suffer from cardiac hypertrophy (as compared to non-failing (NF) human hearts) (Figure 1C,D) and in the mouse hearts suffering cardiac hypertrophy due to biomechanical pressure overload (induced by transverse aortic constriction (TAC)) (Figure 1E,F).