Several studies reported that the combination of aaK130M + V131I (corresponding to A1762T/G1764A mutations), with or without I127T, F132Y, and V5M in the X region, is associated with disease progression to HCC development, and the aaK130M + V131I promotes HCC by activating Akt signaling in a transgenic mouse model [53,54,55]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.