AFP and hepatocellular carcinoma: In 1990, according to the affinity of fucosylated AFP for the Lens culinaris (Lentil) Agglutinin (LCA) lectin, Taketa et al. [106] classified them into LCA-non-reactive (L1), weakly reactive (L2), and strongly reactive (L3) fractions, and showed that the L1 fraction of AFP was increased mostly in chronic hepatitis and cirrhosis, while the L3 fraction was increased in hepatocellular carcinoma.