Analyses of sera from patients with chronic liver disease type B showed that the expression of several miRNAs (miR-21 [131,132], miR-18a, miR-221, miR-222 and miR-224 [133]) and messenger RNA hnRNPH1 expression [134] in EVs were significantly higher in chronic hepatitis B and cirrhosis patients with HCC than chronic hepatitis B and cirrhosis patients without HCC. The gene discussed is HNRNPH1; the disease is chronic hepatitis B virus infection.