TP53 and neoplasm: In a recent detailed review, Scott and Thamalingham summarized present knowledge of low-LET photon-induced hormetic effects mainly involving natural defenses in cells, tissues and whole body and including epigenetically regulated antioxidant production (mitochondria-mediated), DDR with DNA repair selective p53 independent apoptosis of aberrant cells such as transformed and tumor cells, promoting the (mitochondria-dependent) innate and adaptive immune systems with the suppression of inflammatory and the promotion of anticancer immunogenic effects [209].