Below a certain threshold dose of IR (12–18 Gy), the innate immune response is activated in cancer cells [470] including recognition of dsDNA fragments by cyclic GMP-AMP (cGAMP) synthase and the stimulator of interferon genes (STING) sensing cytosolic DNA and mediating the release of type-1 interferon (IFN-1) [471]. The gene discussed is STING1; the disease is cancer.