Anticancer immunity is thought to start with mitochondrial apoptosis as the initiating event, including the induction of MOMP, the release of cytochrome c, macropore formation in the mitochondrial outer membrane accompanied by the release of mtDNA into the cytosol, recognition by the cGAS-STING pathway and cGAMP synthase-driven IFN-1 secretion ensuring final immunogenic cancer cell death [474,476]. The gene discussed is CYCS; the disease is cancer.