In radioresistant cancer cells (p53 mutated or nonfunctional), low-LET IR-induced MOMPs, together with a slight increase in Bax, cytochrome c release and apoptosis, whereas high-LET heavy-ion irradiation with C-ions’ irradiation induced MOMPs more efficiently and intrinsic apoptosis including a significant increase in Bax levels and cytochrome c release [360]. The gene discussed is TP53; the disease is cancer.