A recent randomized, placebo-controlled trial investigation showed that supplementation of ASTN in patients with type 2 diabetes, at a dose of 8 mg per day for 8 weeks, significantly enhanced serum levels of adiponectin and reduced serum triglyceride and very-low-density lipoprotein cholesterol concentration, blood pressure, and visceral body fat accumulation, without adverse effect compared to placebo control [38]. Here, ADIPOQ is linked to type 2 diabetes mellitus.