CD8A and metabolic dysfunction-associated steatohepatitis: In fatty livers of NASH mice, HFD treatment caused a significant increase in both the frequency and cell number of immune cells, including CD3+ T cells, CD8+ T cells, NK1.1+CD3+ natural killer T cells (NKT), and F4/80lowCD11bhigh monocytes-derived macrophages (Figure 5A–D), as well as the number of CD49b+CD3‒ natural killer (NK) cells (Figure 5B).