For example, Shen et al. also reported that ASTN can prevent liver fibrosis by inhibiting the activation of hepatic stellate cells (HSCs) via decreasing transforming growth factor (TGF)-β1 expression and by downregulating autophagy in fibrotic livers from mice treated with carbon tetrachloride (CCl4) or bile duct ligation (BDL) [23]. Here, ASTN1 is linked to Hepatic fibrosis.