ANXA1 and neoplasm: By contrast, low levels of CD206 and CD163 positive macrophages were detected in the ANXA1 KO tumor (panels e–h) and metastasis (panels m–p) tissues, where the main macrophage phenotype was the M1 one, as revealed by CD80 and CD86 signals (panels a, b and i, j for CD80; b, f and k, l for CD86; e, f and m, n for CD163; g, h and o, p for CD206).