CYP7A1 and cholestasis: The activation of the adaptive response was also visible with an upregulation of either NR1I3 or NR1I2 together with the downregulation of CYP7A1 and SLC10A1, which could be considered an attempt to counteract the BA accumulation derived from the concomitant ABCB11 downregulation, known as a trigger of cholestasis [17].