We observed the B-cell receptor (BCR) signaling pathway, Fc gamma R-mediated phagocytosis, endocytosis, ErbB signaling, and natural killer cell-mediated cytotoxicity pathways were more enriched for regulated proteins in DLBCL EVs compared to the whole-cell proteome (Figure 5). The gene discussed is EGFR; the disease is diffuse large B-cell lymphoma.