Microglia infiltration is elevated in estrogenic GBM, with levels elevated >40%, p < 0.001, and we observe >30% NF-κB signaling in estrogenic GBM, p < 0.001, Figure 3C. Unlike combinatorial estrogen and progesterone, combined androgen and progesterone has a synergistic effect on microglia NF-κB signaling, with the difference between A&P and E&P groups being 3:1, p < 0.001. The gene discussed is NFKB1; the disease is glioblastoma.