ITPR1 and neoplasm: NKA-associated Src phosphorylation activates intracellular signaling molecules including epidermal growth factor receptor (EGFR), Inositol 1,4,5-trisphosphate receptor (IP3R), phospholipase C-γ (PLC-γ), and phosphatidylinositol 3-kinase (PI3K), which promote increased cell volume, cell proliferation, and tumor progression [29,30,31,32].