Interestingly, previous evidence has suggested that tumor necrosis factor (TNF), receptor-associated factor 6 (TRAF6), and enhancer of the zeste homolog 2 (EZH2) are key players in the upregulation of miR-429-3p in HFD-induced obesity [42]. The gene discussed is TRAF6; the disease is obesity due to melanocortin 4 receptor deficiency.