CDH1 and hepatocellular carcinoma: In addition to Cdh1, other cytoskeleton-related genes are silenced by DNA hypermethylation, e.g., Connexin26 in rat hepatocellular carcinomas is induced by choline-deficient diets [581], and Cdh13 hypermethylation (CADHERIN-13) correlates negatively with hormone receptor status in breast cancers [582].