Using a mouse model of pancreatic ductal adenocarcinoma and CRISPR/Cas9 sgRNA to screen epigenetic modifiers, Yuan et al. [569] identified the nuclear receptor binding SET domain protein 2 (NSD2) as the top gene significantly enriched in a subpopulation of cells showing the epithelial marker E-CADHERIN (ECAD+). This evidence concerns the gene NSD2 and pancreatic ductal adenocarcinoma.