Le Boiteux et al. [604] report that the DNA sequence of Hox gene clusters are hypermethylated and silenced (except for Hoxd1 and Hoxd-As1) in normal brain samples, but among the 57 HOX transcripts (39 sense and 18 antisense) a median of 37 transcripts was deregulated in the HOX clusters from the isocitrate dehydrogenase (IDH) wild type glioma samples. This evidence concerns the gene IDH3A and central nervous system cancer.