As a result, the level of promoter methylation for Micb, Ulbp1 and Ulbp3 is higher in gliomas with mutated IDH than with wild type IDH, and the two primary transcriptionally silenced NKG2D ligands ULBP1 and ULBP3 were responsive to DNMTi [546]. This evidence concerns the gene ULBP3 and glioma.