CTCF and neoplasm: It has been suggested that the transfer of epigenetic methylating or hypomethylating enzyme complexes across normal genomic boundaries (limited by CCCTC-binding factor (CTCF) [17], or by differential methylation vs. hydroxymethylation abundance [18]) could favour spreading of DNA hypomethylation (in oncogene promoters) or hypermethylation (in enhancers or promoters of tumor suppressor genes) in adjacent genomic areas [19,20,21,22,23].