The cyclin-dependent kinase inhibitors (CDKI) p14Arf (p19Arf), p15Ink4b, p16Ink4a, and the long non-coding RNA ANRIL (antisense non-coding RNA in the INK4 locus) are four genes transcribed from the Ink4b/Arf/Ink4a locus, considered by some as the most frequently mutated locus (MYC amplifications and Cdkn2a/b deletions in 14% of 3131 cancer samples [491]), while p16Ink4a is epigenetically silenced in more than 70% of cases, depending on cancer types [492,493]. The gene discussed is CDKN2B-AS1; the disease is cancer.