Additional antigen-processing and -presentation molecules that can be regulated by DNA methylation include B2M (beta-2 microglobulin), CALR (calreticulin, a reticulum endoplasmic protein), CD58 (alias LFA-3, lymphocyte function-associated antigen 3), PSMB8, and PSMB9 (Proteasome subunit beta type-8, -9), which were found upregulated following DNMTi exposure in colon and ovarian cancer cell lines [524]. The gene discussed is CALR; the disease is ovarian cancer.