In human cells, satellite DNA overexpression is observed during stress, senescence, aging, and in various cancers associated with deregulation of epigenetic enzyme activities (e.g., DNMT3B, KDM2A, JMJD2B, SIRT6, GCN5, BRCA1, PRC1, and PRC2) [174]. Here, BRCA1 is linked to cancer.