Regarding RNA editing, ADAR2 downregulation with a concomitant expression of Q/R site-unedited GluA2 mRNA was reported in the motor neurons of ALS patients carrying the FUSP525L mutation [121] but not in motor neurons differentiated from iPSCs derived from ALS patients carrying FUSH517D mutation [113]. The gene discussed is ADARB1; the disease is amyotrophic lateral sclerosis.