Furthermore, reduced ADAR2 activity due to the loss of nuclear ADAR2 rather than a decrease in ADAR2 expression was reported the cause of a widespread reduction in RNA editing with ADAR2 cytoplasmic mislocalization in the motor neurons and differentiated motor neurons, which were generated from iPSCs derived from ALS patients carrying C9ORF72 with enhanced hexanucleotide repeat expansion [122]. The gene discussed is ADARB1; the disease is amyotrophic lateral sclerosis.