SOX2 and non-small cell lung carcinoma: We also observed that the two-gene signature of SLC7A5 and CD274 displayed positive correlations with EZH2, c-Myc, and SOX2 in the NSCLC dataset of the TCGA database (Figure S4), which further supports the conjecture that LAT1+/PD-L1+ is a CSC marker in NSCLC cells.