HMOX1 and Alzheimer disease: For example, HO-1 was overexpressed in AD patients’ brains, mainly in the hippocampus and cerebral cortex, and co-localized to neurons, GFAP-positive astrocytes, choroid plexus epithelial cells, ependyma, corpora amylacea, neurofibrillary tangles, and senile plaques [46,47].