EGFR and neoplasm: Both natural (ursolic, glycyrrhetinic, and oleanolic acids, lupeol, and dimethyl melaleucate) and semisynthetic PTs were found to inhibit tumor cell growth by decreasing phosphorylation of EGFR leading to suppression of downstream signaling (MAPK, PI3K/Akt/NF-κB and/or STAT) pathways [26].