For example, miR-145-5p was reported to directly downregulate the expression of E2F3 by seed-matching the 3′-untranslated region (UTR) of E2F3 in osteosarcoma cells, and cell growth was inhibited and G0/G1 arrest occurred when E2F3 was suppressed by miR-145-5p. Here, E2F3 is linked to osteosarcoma.