Apart from CRP, interleukin (IL)-2, IL-6, IL-8, and soluble IL-2 receptor α (sIL-2Rα), tumour necrosis factor (TNF)-α, hepatocyte growth factor (HGF), platelet-derived growth factor, vascular endothelial growth factor and tumour growth factor β (TGF-β) are also overexpressed in MPN Ph-negative patients [12,16,17,60,67,68,69]. The gene discussed is TNF; the disease is myeloproliferative disorder.