The diagnostic criteria of anti-NMDAR encephalitis were developed in 2016 and primarily made by the detection of IgG antibodies to the GluN1 (also known as NR1) subunit of the NMDAR in serum or CSF, with the exclusion of recent history of herpes simplex virus encephalitis or other encephalitides, which might result in relapsing immune-mediated neurological symptoms (Table 3) [27,28]. Here, GRIN1 is linked to herpes simplex encephalitis.