Indeed, it has been demonstrated that patients with lung cancers or melanomas with a high mutational load experience a higher rate of response to immune checkpoint blockade [7], and in pancreatic cancer, it was recently determined that tumors with both the highest neoantigen number and the most abundant DCs and CD8+ T-cell infiltrates corresponded with the longest patient survival [74]. Here, CD8A is linked to familial pancreatic carcinoma.