In the present study, plasma CDCA, CA, LCA, and GCDCA increased significantly in the HP+BAs group; with the assistance of enterohepatic circulation of Bas [63], they will enter the liver and activate TGR5, especially LCA, that cannot be synthesized directly in the liver while it can only be recovered from intestinal BAs by blood circulation, thus enhancing the anti-inflammatory ability of the body, regulating glucose metabolism and reducing blood glucose, and decreasing the liver inflammation [64]. Here, GPBAR1 is linked to Hepatitis.