On the other hand, it was demonstrated that isomers of tetra-p-coumaroyl thermospermines and tetra-p-coumaroyl spermines are promising antagonists, exerting positive effects on substance P/neurokinin-1 receptor-related diseases, including HER2- positive cancers, pain, mood disorders, and insomnia [47]. The gene discussed is TACR1; the disease is insomnia.