SERPINF1 and diabetes mellitus: Accordingly, He et al. [144] had found that, in mice affected by streptozotocin-induced diabetes and treated to obtain an injury at the corneal level, the topical application of DHA combined with pigment epithelium-derived factor (PEDF) for 2 weeks markedly accelerated corneal epithelium WH (time to complete closure of epithelial injury, 49 days in DHA+PEDF rats vs. 61 days in control rats).