The targeting mechanism of NP was enabled by including, in the lipid membrane, lipopeptides targeting the HER2 [14]: during circulation in the blood, the functionalized lipids were shown to be uniformly dispersed on the surface of NP, which were not particularly active towards HER2, and, when in the tumor interstitium, the functionalized lipids preferentially partitioned into phase-separated lipid domains forming ‘patches’ with high local peptide valency, resulting in long binding times of the patch (in a single NP) to a single HER2 receptor followed by cell internalization. Here, ERBB2 is linked to neoplasm.