Beyond their roles as scavenger phagocytes in neuropathologies, these cells have been shown to play a role in hypertension-associated neurovascular and cognitive dysfunction, activation of the paraventricular nucleus of the hypothalamus, and corticosterone and noradrenaline release after systemic IL-1β administration or myocardial infarction in rodents [36]. The gene discussed is IL1B; the disease is hypertensive disorder.