Luo and colleagues demonstrated that either gemfibrozil or Wy14643 reverse not only memory deficits, but also amyloid plaque pathology and anxiety in the APP-PSEN1ΔE9 model (co-expressing the Swedish APP mutation and exon 9 deletion of the PSEN1 gene) via a PPARα-dependent enhancement of autophagosome biogenesis [124]. Here, APP is linked to Anxiety.