Lately, PPARα agonists have been proposed as a novel disease-modifying target for sleep-related hypermotor epilepsy (SHE), formerly referred to as nocturnal frontal lobe epilepsy (NFLE), idiopathic epilepsy with an autosomal inherited component, based on the effectiveness of fenofibrate in an NFLE mouse model and as an adjunctive therapy in pharmacoresistant NFLE patients [120]. The gene discussed is PPARA; the disease is sleep-related hypermotor epilepsy.