Accordingly, the PPARγ agonist, MDG548, and the PPARα/γ dual agonist, MHY908, exert neuroprotective effects by boosting phagocytosis and anti-inflammatory cytokines production, and by reducing microglial activation and neuroinflammation in MPTP mouse models of PD, thus attenuating neuronal damage and motor deficit [167,168]. The gene discussed is PPARA; the disease is Parkinson disease.