Brain 2-AG levels are 170 times higher than those of AEA, and the activation of the CB1 and CB2 receptors by 2-AG is associated with many physiological processes, including inflammation, food intake, locomotor activity, learning and memory, epileptogenesis, neuroprotection, pain sensation, mood, stress and anxiety, and addiction and reward [67]. The gene discussed is CNR1; the disease is Anxiety.