For example, it was reported that ginsenoside Rg5 inhibits NF-kB signaling in macrophages, human epidermal keratinocytes, HeLa, A549, and 293T cancer cells at the concentration 20–50 μM [38,39,40] (Table S1 in Supplement 1), but in our study ginsenoside, Rg5 induces mild upregulation (53- to103--fold) of Nfkb2 gene expression both at low and highest concentrations (10 aM, 1 fM, 1 pM, and 100 μM). Here, NFKB1 is linked to cancer.