This is supported by the concept that the main pro-angiogenic factors such as vascular endothelial growth factor (VEGF), placenta growth factor (PlGF), and platelet-derived growth factor (PDGF) are produced and released by several liver cell types involved in the progression of chronic liver disease (CLD), such as hypoxic hepatocytes, hypoxia-sensitive macrophages, and hepatic myofibroblasts (MF) [15,16,17]. The gene discussed is PGF; the disease is congenital secretory chloride diarrhea 1.