Following oxidative stress, TXNIP is involved in the different signaling pathways which are engaged in a diversity of neuronal dysfunction [20,30].Moreover, TXNIP is required for activation of the NOD-like receptor protein 3 (NLRP3)-inflammasome, a multi-protein complex involved in instigating inflammation and immune regulation in several neurovascular injury models including stroke [5,20,21,31]. Here, NLRP3 is linked to Stroke.