Combinatorial treatment of curcumin and docetaxel in oesophagal squamous cell carcinoma mitigated the migration, invasion of cancer cells and further induced apoptosis, autophagy-mediated through PI3K/AKT/mTOR pathway, where inhibition of autophagy was found to increase the apoptosis indicating the activation of pro-survival autophagy upon drug treatment [151]. This evidence concerns the gene MTOR and cancer.