In human colon carcinoma cells (HCT-116 cells), curcumin-mediated cytotoxicity was attenuated by the expression of c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase associated protein 1 (JSAP1), a scaffold protein involved in JNK signaling pathway and lysosomal transport with an increase in autophagy. Here, MAPK8IP3 is linked to colon carcinoma.