Quercetin treatment promoted the expression of Apoptosis-Stimulating Protein of p53-1 (ASPP-1), an activator of p53 through the activation of the zinc-finger nuclear transcription factor Early Growth Response-1 (EGR-1) and exhibited cytotoxicity in human colorectal carcinoma cells. The gene discussed is EGR1; the disease is colorectal carcinoma.