NFE2L2 and neoplasm: Our data indicated that, in tumor tissue subjected to SDT, the NFE2L2 gene was upregulated (Figure 5), suggesting an increase in the half-life of Nrf2, a transcription factor able to translocate into the nucleus under stress, binding the antioxidant response element (ARE) in order to activate the transcription of cytoprotective genes, such as NQO1, GST-1, and x-CT, establishing the pro-oxidant conditions in tumor tissue after SDT [42].