Although the exact mechanism underlying SDT is still unclear, there is a wide consensus that ROS play a pivotal role in the sonodynamic-induced anticancer effect; therefore, to establish if a reduction in tumor growth was mainly attributable to oxidative stress in the syngeneic model of breast cancer subjected to SDT, mRNA expression of genes associated with oxidative stress, such as NFE2L2 and NQO1 genes, were investigated [4,21]. This evidence concerns the gene NFE2L2 and neoplasm.