HIF1A and neoplasm: Our results showed a statistically significant downregulation of HIF-1α mRNA expression in tumor tissue at 72 h after SDT (day 11) compared to the control animal group (p ≤ 0.01, Figure 4A), and no statistically significant change in VEGF protein expression in tumor tissue at 72 h after SDT (day 11) compared to the control animal group (Figure 4B).