In another meta-analysis, Amirani et al. [19] reported that taking probiotics by patients with different psychiatric disorders (not only MDD) had beneficial effects on C-reactive protein (CRP), IL-10 and malondialdehyde (MDA) levels, but it did not affect other markers of inflammation (TNF-alpha, IL-1B) and oxidative stress. The gene discussed is TNF; the disease is major depressive disorder.