In the present meta-analysis, the comparative effectiveness of G-CSF drugs (FIL versus PCT/NT; FIL versus PEG-F; FIL versus Bio-F) for cancer patients receiving chemotherapy in 56 studies containing 13,058 patients were evaluated, using FN, grade 3 or 4 neutropenia and bone pain as indicators. Here, CSF3 is linked to Decreased total neutrophil count.