This viewpoint is strengthened by the fact that pathological forms of tau can independently lead to neurodegenerative disorders, collectively referred to as primary tauopathies which include conditions such as corticobasal degeneration (CBD), Pick’s Disease (PiD), progressive supranuclear palsy (PSP), and frontotemporal lobar degeneration with tau pathology (FTLD-tau) [6,7,8]. This evidence concerns the gene MAPT and Pick disease.