ACE2 and congestive heart failure: The overexpression of angiotensin converting enzyme type 2 (ACE2), the enzyme responsible for converting Ang-II into Ang-(1–7), in the PVN, stabilized the reduction in nNOS protein expression in the PVN in animals with chronic heart failure and was accompanied by improved sympathetic nerve activity, suggesting the participation of NO in the inhibitory effects of ACE2 in the sympathoexcitation [120,121].