Serum levels of VICM (MMP-2/8 degraded and citrullinated-vimentin), C3M and C4M (MMP-9 degraded collagen type IV) discriminate CD from UC, and C1M (MMP-9 degraded collagen type I) and C3M discriminate UC from non-IBD [72]. Here, MMP9 is linked to inflammatory bowel disease.