Friedreich ataxia (FRDA) is a recessive neurodegenerative disorder associated with hypertrophic cardiomyopathy and is caused by a GAA repeat expansion in the first intron of the Frataxin (FXN) gene, which encodes a mitochondrial protein involved in iron-sulfur cluster biosynthesis [136,137]. This evidence concerns the gene FXN and hypertrophic cardiomyopathy.