The survival analysis using univariate Cox analysis was performed for five potential hub genes (TOP2A, RRM2, NEK2, CDK1, and CCNB1) obtained from gene co-expression and PPI networks, and three other genes of the top ten genes with the highest intramodular connectivity (RFC4, PRIM1, and KIF14) in HCC. This evidence concerns the gene RFC4 and hepatocellular carcinoma.