GABARAPL1 and neoplasm: Since GABARAPL1 has been previously described as a tumor suppressor gene in breast cancer and hepatocellular carcinoma cell lines [46,47], we therefore studied the effect of the knockout of GABARAPL1 in our lung adenocarcinoma cell line A549, and found that the A549 KO GABARAPL1 cells presented a higher proliferation rate than the control A549c cells (Figure 7A).