Moreover, in the last decades, there has been a major paradigm shift in the management of metastatic non-small cell lung cancer (NSCLC), with the advent of targeted therapies for patients harbouring druggable alterations such as EGFR or BRAF mutations, as well as ALK, ROS, and RET rearrangements, and so on [7]. The gene discussed is ROS1; the disease is non-small cell lung carcinoma.