PCSK9 and Atherosclerotic lesion: Contrary, in LLD+/AF+ was found significant decline in majority of proatherogenic markers, such as LDLR, PCSK9, MMP-3, VEGF-D, and SORT1, which are implicated in LDL cholesterol metabolism, VLDL and PCSK9 secretion and the development of atherosclerotic lesions [21,22].