In these transgenic mice, the cell cycle progression of cortical progenitors was also impaired, and a ChIP-seq analysis indicated that Olig2 occupied the promoter or enhancer regions of Nfatc4, Pax6, Dyrk1a, and Rcan1 genes that are related to reduced neurogenesis in DS [68]. This evidence concerns the gene DYRK1A and Dravet syndrome.