HPV integration events affect all chromosomes, including some previously described at 3q26.31 (TERC, MECOM), 3q28 (TP63), 8q24.21 (MYC, PVT1), 11q22.1 (YAP1, BIRC2, BIRC3), and 17q12 (ERBB2) in cervical cancer and recurrent focal amplification events have been identified at 7p11.2 (EGFR), 9p24.1 (CD274, PDCD1LG2), 13q22.1 (KLF5), and 16p13.13 (BCAR4). The gene discussed is CD274; the disease is cervical carcinoma.