TSC2 and renal cell carcinoma: In a second paper, Tjota et al. [37] analyzed eight more cases of RCC with abundant granular eosinophilic cytoplasm, originally diagnosed as ChRCC, and found mutations in TSC1 in 1/8 (12%), in TSC2 in 3/8 (37%), and in mTOR in 4/8 (50%) cases.