Alström syndrome (OMIM 203800) is an autosomal-recessive disorder associated with impaired GH reserve [116,122], and is characterized by progressive cone-rod dystrophy, SNHL, insulin resistance with hyperinsulinemia, type 2 diabetes, cardiomyopathy, and progressive hepatic and renal failure [123,124]. The gene discussed is GH1; the disease is sensorineural hearing loss disorder.