Mutations in GHR cause Laron syndrome, a rare disease (ORPHA:633) characterized by marked short stature, low serum IGF-1 levels and auditory defects like late onset SNHL, auditory hypersensitivity and lack of acoustic stapedial reflexes, which may be prevented by IGF-1 treatment [69]. The gene discussed is IGF1; the disease is sensorineural hearing loss disorder.