A prospective clinical study testing auditory function in patients with congenital IGF-1 deficiency in the early-treated, late-treated and untreated states revealed an association between Laron syndrome and SNHL, auditory hypersensitivity and lack of acoustic stapedial reflexes, and concluded that IGF-1 replacement therapy at early developmental age could prevent Laron syndrome [69]. This evidence concerns the gene IGF1 and sensorineural hearing loss disorder.