Besides the known alcohol metabolism genetic variant, rs671, we identified 12 SNPs located on the ALDH4A1, ALDH18A1, ALDH3B2, ALDH1L2, and ALDH1A2 genes from the ALDH multigene family that were associated with an elevated NPC risk. This evidence concerns the gene ALDH18A1 and nasopharyngeal carcinoma.