Besides the known alcohol metabolism genetic variant, rs671, we identified 12 SNPs located on the ALDH4A1, ALDH18A1, ALDH3B2, ALDH1L2, and ALDH1A2 genes from the ALDH multigene family that were associated with an elevated NPC risk. The gene discussed is ALDH3B2; the disease is nasopharyngeal carcinoma.