However, SNP rs1229884 in the ADH1B gene was not significantly associated with NPC in our Han Chinese patients in Taiwan, which is consistent with the results from previous meta-analyses showing that the ALDH2 polymorphism, but not the ADH1B polymorphism, significantly increases the risk of CRC in East Asians [14,35]. Here, ADH1B is linked to nasopharyngeal carcinoma.