The Venn diagram demonstrated one upregulated DEG, KIAA0319, which was upregulated in both L444P/N GBA-PD patients and L444P/N GBA carriers compared to the controls and two DEGs, DUSP1 and ARL4C, which were downregulated in L444P/N GBA-PD patients compared to both L444P/N GBA carriers and controls (Figure 3A). This evidence concerns the gene DUSP1 and Parkinson disease.