Here, we first generated the transcriptomic profiles for GBA-PD patients, asymptomatic GBA mutation carriers (GBA carriers), and controls in monocyte-derived macrophages, in order to investigate what variations in monocyte-derived macrophage transcriptomes can be attributed to the presence of GBA mutation and what can be viewed as a trigger of PD in GBA mutation carriers. This evidence concerns the gene GBA1 and Parkinson disease.