It is worth noting that RNA-seq revealed the difference between transcriptomic profiles in the peripheral blood of symptomatic and asymptomatic G2019S LRRK2 mutation carriers and identified common differentially expression genes functionally involved in the pathways and related with LRRK2-PD pathogenesis, such as Akt signaling, glucose metabolism, or immunity [14,15]. The gene discussed is LRRK2; the disease is Parkinson disease.