Among 48 candidate genes, there were 27 candidate genes (AEBP1, AGRN, AMPH, CHST2, COL25A1, CPLX1, FAM110B, GFRA1, GLRB, GRASP, GSG1L, IRF4, IRX5, LMO1, MPPED2, PPP2R5C, PREX2, PTPRN2, RALYL, SND1, SPOCK1, THBD, TLL1, TLX1, USP44, VIPR2, and VSX1) with less known roles in the management of colorectal cancer. The gene discussed is TLL1; the disease is colorectal cancer.