Fifth, according to our biomarker selection approach, ADHFE1, SDC2, and PPP2R5C are supposed to display hypermethylation in the CRC tissues from white, Asian, and black populations; however, 5% of ADHFE1, 10% of SDC2, and 10% of PPP2R5C methylation levels in CRC tissues from the white population did not coincide with these findings. Here, SDC2 is linked to colorectal carcinoma.