Initial studies investigating a potential role of germline BRCA1 and BRCA2 PGVs also for predisposition for non-syndromic childhood cancer focussed on the incidence of childhood cancers in the offspring of families presenting with HBOC, in which a germline BRCA1/2 PGV had been detected. The gene discussed is BRCA1; the disease is childhood malignant neoplasm.