Whilst not demonstrating causality, as the germline BRCA2 status of affected children was not known and the possibility that there may be linked variation in modifier genes in affected families as demonstrated for HBOC BRCA2 families [56], this was the first suggestion of an association of BRCA2 PGVs with childhood cancer predisposition. This evidence concerns the gene BRCA2 and childhood malignant neoplasm.