In contrast to the more common defects in the FA-core complex genes including FANCA, FANCC or FANCG, the malignancies in BRCA2-associated FA include in addition to early AML also Wilms’ Tumour, embryonal brain tumours, (mostly medulloblastoma but also glioblastoma), hepatoblastoma, T-cell acute lymphoblastic leukaemia (ALL), neuroblastoma, and two cases of individuals with rhabdomyosarcoma have been reported [21,22,23,24,25,26,27,31,32,33]. This evidence concerns the gene BRCA2 and acute myeloid leukemia.