While the cancer spectrum encountered by individuals affected by bi-allelic BRCA1 PGVs includes also two individual cases of T-cell ALL and neuroblastoma [41,47], which are encountered in BRCA2-associated and also in FANCN/PALPB2 -associated FA [46], the other reported individuals have developed more characteristic HBOC-associated adult-type epithelial malignancies early in life, such as breast and ovarian cancer [41,51]. Here, PALB2 is linked to cancer.